A histologically hostile environment made more hospitable?

Last updated: 05-19-2020

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A histologically hostile environment made more hospitable?

A histologically hostile environment made more hospitable?
Up to one-third of patients with diabetes mellitus will develop a diabetic foot ulcer in their lifetime. While this number appears to be rising, breakthrough therapies for this common, complex and costly condition have been, to this point, elusive.
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References
1.
Armstrong, D. G., Boulton, A. J. M. & Bus, S. A. Diabetic foot ulcers and their recurrence. N. Engl. J. Med. 376, 2367–2375 (2017).
Google Scholar
2.
Skrepnek, G. H. et al. Health care service and outcomes among an estimated 6.7 million ambulatory care diabetic foot cases in the US. Diabetes Care 40, 936–942 (2017).
Google Scholar
3.
Armstrong, D. G. et al. Mind the gap: disparity between research funding and costs of care for diabetic foot ulcers. Diabetes Care 36, 1815–1817 (2013).
Google Scholar
4.
Sen, C. K. et al. Human skin wounds: a major and snowballing threat to public health and the economy. Wound Repair Regen. 17, 763–771 (2009).
Google Scholar
5.
Sessions, J. W. et al. A review of genetic engineering biotechnologies for enhanced chronic wound healing. Exp. Dermatol. 26, 179–185 (2017).
Google Scholar
6.
Zhu, Y. et al. Potent laminin-inspired antioxidant regenerative dressing accelerates wound healing in diabetes. Proc. Natl Acad. Sci. USA 115, 6816–6821 (2018).
Google Scholar
7.
Michaels, J. et al. db/db mice exhibit severe wound-healing impairments compared with other murine diabetic strains in a silicone-splinted excisional wound model. Wound Repair Regen. 15, 665–670 (2007).
Google Scholar
8.
Ansell, D. M., Holden, K. A. & Hardman, M. J. Animal models of wound repair: are they cutting it? Exp. Dermatol. 21, 581–585 (2012).
Google Scholar
9.
Armstrong, D. G. et al. The quest for tissue repair’s holy grail: the promise of wound diagnostics or just another fishing expedition? Wound Med. 8, 1–5 (2015).
National Institutes of Health. RFA-DK-17-014: Diabetic Foot Consortium — Clinical Research Units (U01) (NIH, 2018).
11.
Gomes, A. et al. Wound-healing peptides for treatment of chronic diabetic foot ulcers and other infected skin injuries. Molecules 22, 1743 (2017).
Author information
Affiliations
Southwestern Academic Limb Salvage Alliance (SALSA), Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA
David G. Armstrong
Department of Surgery, Stanford University College of Medicine, Stanford, CA, USA
Geoffrey C. Gurtner
The authors declare no competing interests.
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Armstrong, D.G., Gurtner, G.C. A histologically hostile environment made more hospitable?. Nat Rev Endocrinol 14, 511–512 (2018) doi:10.1038/s41574-018-0073-6
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