Gout May Increase A-Fib Risk

Last updated: 10-14-2020

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Gout May Increase A-Fib Risk

We’ve discussed how some foot conditions can lead to other related issues on the blog before, and new research out of the UK has linked another foot problem to a dangerous heart ailment.

According to researchers out of Great Britain, people with gout in their feet may be at an increased risk for atrial fibrillation (Afib). When looking at a collection of health data from people treated for gout, researchers noted that those treated for the foot condition were much more likely to also have Afib compared to the control group.

For their study, researchers analyzed health data of more than 45,000 people with gout and more than 45,000 people without the condition. When cross-examined for other potential health complications, researchers uncovered:

7.42 percent of people with gout also had Afib. Only 2.98 percent of the control population was diagnosed with Afib.

The prevalence held through across both sexes. For men, the percentages were 6.69 percent compared to 2.49 percent, and for women the percentages were 9.36 percent compared to 3.71 percent.

In general, gout patients consumed more cigarettes, drank more alcohol and had a higher body mass index than controls.

Patients with gout were also more likely to be diagnosed with hypertension, ischemic heart disease, cerebrovascular disease, heart failure, and valvular heart disease compared to controls.

Another study revealed that after 5 years from the date of diagnosis, about 12% of gout patients developed Afib compared with only 6% of matched controls.

Lead researcher Dr. Weiya Zhang and colleagues did not know exactly why gout was linked to Afib prevalence, but they have some speculations.

“Currently, there is no explicit explanation for the link between gout and Afib,” said Zhang. “The potential mechanism underlying the increased risk of Afib in gout patients is hyperuricemia. Increasing evidence suggests that uric acid participates in the atrial remodeling process that enhances the risk of Afib.”

Researchers concluded that doctors should keep the study in mind, and older patients who develop gout should also be screened for Afib.

“[The study makes] the case for a clinical cardiovascular assessment and inclusion of an electrocardiogram as a part of the initial assessment of gout patients at diagnosis and close observation … for the occurrence of incident Afib, especially for the elderly and those having other Afib risk factors,” they wrote.


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